As in previous studies, we have shown that AM from patients with pulmonary alveolar proteinosis have decreased phagocytic ability in vitro. The acridine orange assay allows for a direct quantitative assessment of phagocytosis, and the present data show no differences in the proportion of macrophages from pulmonary alveolar proteinosis, compared with normal human AM, ingesting yeast; but the total phagocytic activity is decreased because macrophages from pulmonary alveolar proteinosis, on the average, ingest fewer yeast cells. Golde and co-workers did not find this type of abnormality with a 60-minute challenge, but Harris and Nugent and Pesanti did when AM were challenged with bacteria for two or more hours. At the time of the phagocytosis assays, the AM from patients with pulmonary alveolar proteinosis had been […]

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