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	<title>Depression</title>
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		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: CONCLUSIONS Part 2</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-conclusions-part-2-201.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-conclusions-part-2-201.html#comments</comments>
		<pubDate>Wed, 16 May 2012 11:26:15 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=201</guid>
		<description><![CDATA[Regarding core mutants: • Mutations to the core gene are less common than mutations in other areas of the viral genome. • Core mutants appear to be associated with viral escape from immune surveillance and are relevant to the response (or lack thereof) to interferon therapy. Regarding DNA-P mutations: • DNA-P mutations are uncommon in [...]]]></description>
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		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: CONCLUSIONS Part 1</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-conclusions-part-1-188.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-conclusions-part-1-188.html#comments</comments>
		<pubDate>Tue, 15 May 2012 13:23:34 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=188</guid>
		<description><![CDATA[Available data allow the following conclusions to be made regarding the S escape mutant. • The mutants constitute an increasing percentage of ‘vaccine failures’, but their prevalence in the general population does not appear to be increasing. • The overall prevalence in HBV-vaccinated Southeast Asian children born of HBV carrier mothers appears to be low [...]]]></description>
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		<slash:comments>0</slash:comments>
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		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: HBcAg mutants</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbcag-mutants-187.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbcag-mutants-187.html#comments</comments>
		<pubDate>Sat, 12 May 2012 12:45:03 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=187</guid>
		<description><![CDATA[HBcAg mutants The most immunodominant epitopes of HBcAg are between amino acids 50 and 69, and 61 and 85. Mutations in this region have been described in HBV patients with active hepatitis but not during the immune-tolerant phase of the infection. If the mutations, which likely occur as a result of B and T cell [...]]]></description>
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		<slash:comments>0</slash:comments>
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		<title>Hepatitis B viral mutants and their relevance: Precore and core promoter mutants Part 2</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-precore-and-core-promoter-mutants-part-2-186.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-precore-and-core-promoter-mutants-part-2-186.html#comments</comments>
		<pubDate>Thu, 10 May 2012 13:45:36 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=186</guid>
		<description><![CDATA[Although initially described in association with histologically active liver disease, including fulminant hepatic failure, the precore mutant has more recently been identified in chronic HBV carriers without biochemical or histological evidence of liver disease. Indeed, in a recent population-based study of Canadian Inuit, none of the approximately 35 precore mutant carriers identified had clinical or [...]]]></description>
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		<slash:comments>0</slash:comments>
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		<title>Hepatitis B viral mutants and their relevance: Precore and core promoter mutants Part 1</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-precore-and-core-promoter-mutants-part-1-185.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-precore-and-core-promoter-mutants-part-1-185.html#comments</comments>
		<pubDate>Tue, 08 May 2012 12:11:10 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=185</guid>
		<description><![CDATA[More mutations of the viral genome may be tolerated in the large region of the precore/core ORF, which is not overlapped by another ORF. The most common and extensively studied of these is the glycine to arginine point mutation at nucleotide 1896 of the precore region that transforms codon 23 from tyrosine-glycine-glycine to a tyrosine-argi-nine-glycine [...]]]></description>
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		<slash:comments>0</slash:comments>
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		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: S mutants Part 2</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-s-mutants-part-2-176.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-s-mutants-part-2-176.html#comments</comments>
		<pubDate>Mon, 07 May 2012 12:12:29 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=176</guid>
		<description><![CDATA[The study that has most extensively documented the prevalence of S escape mutants is that reported by Hsu et al. Investigators studied approximately 1500 stored sera sampled from children just before universal HBV vaccination in their country (1984), and from similar sized groups of children belonging to the same age groups five and 10 years [...]]]></description>
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		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: S mutants Part 1</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-s-mutants-part-1-175.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-s-mutants-part-1-175.html#comments</comments>
		<pubDate>Sat, 05 May 2012 13:58:36 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=175</guid>
		<description><![CDATA[The target of the host’s humoral response to HBV is the hydrophilic region of HBsAg between amino acid residues 100 and 160, the so-called ‘a’ epitope. Thus, a distinct survival advantage would be afforded to HBV variants with mutation(s) in this (more precisely between amino acid residues 124 and 147) or adjacent regions that interfere [...]]]></description>
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		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: HBV MUTANTS Part 2</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbv-mutants-part-2-164.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbv-mutants-part-2-164.html#comments</comments>
		<pubDate>Thu, 03 May 2012 13:12:39 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=164</guid>
		<description><![CDATA[The second, perhaps more relevant, explanation for the perceived paucity of HBV mutants relates to the unique structure of the HBV genome. The compact nature of the genome (Figure 1) defines four overlapping open reading frames (ORF). These ORFs encode the envelope (pre-s/s), core (pre-c/c), polymerase and X proteins. The extent of the overlap is [...]]]></description>
		<wfw:commentRss>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbv-mutants-part-2-164.html/feed</wfw:commentRss>
		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: HBV MUTANTS Part 1</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbv-mutants-part-1-163.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbv-mutants-part-1-163.html#comments</comments>
		<pubDate>Wed, 02 May 2012 13:20:15 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=163</guid>
		<description><![CDATA[The half-life of HBV in the blood has been estimated to be one day. As HBV-DNA levels tend to be relatively constant, given an average viral load, approximately 1011 HBV particles must be released into the circulation daily. Thus, considerable viral replication is presumed to be underway within the liver. With each replicative cycle, the [...]]]></description>
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		<slash:comments>0</slash:comments>
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		<title>Hepatitis B viral mutants and their relevance to the Canadian health care system: HBeAg</title>
		<link>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbeag-157.html</link>
		<comments>http://www.depressionofspirits.com/hepatitis-b-viral-mutants-and-their-relevance-to-the-canadian-health-care-system-hbeag-157.html#comments</comments>
		<pubDate>Tue, 01 May 2012 13:18:26 +0000</pubDate>
		<dc:creator>Richard</dc:creator>
				<category><![CDATA[Hepatitis B virus]]></category>

		<guid isPermaLink="false">http://www.depressionofspirits.com/?p=157</guid>
		<description><![CDATA[HBeAg An additional antigen used in HBV serological testing is HBeAg. As discussed above, HBeAg consists of a large amino acid peptide that is synthesized and secreted by hepatocytes in proportion to the extent of viral replication. Thus, the presence and quantity of HBeAg in the circulation reflect the level of viral replication and, therefore, [...]]]></description>
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