Octreotide and other somatostatin analogues inhibit growth hormone and suppress the secretion of serotonin and many other gastrointestinal peptides. These agents are extensively used in the management of variceal bleeding because they decrease splanchnic blood flow and, thus, portal venous pressure. Somatostatin immunoreactivity has been reported in submucosal plexus neurons associated with the lymphatic vessels of guinea pig ileum; of the multiple subtypes of somatostatin receptors, types two and five are the most common in the gastrointestinal tract. Thus, this suggests that somatostatin (and analogues) could affect lymphatic function. To investigate whether octreotide alters lymphatic pumping function, we applied varying doses of octreotide to lymphatic vessels of the ileal portion of the guinea pig mesentery. This preparation is a well established model used to characterize both physiological and pharmacological properties of lymphatic pumping . Lymphatic vessels in this preparation range from 100 pm to 300 pm in diameter. The vessels are segmented into chambers (length 150 pm to 500 pm) by unidirectional valves. These vessels undergo rhythmic constrictions of five to 20 constrictions/min when luminal perfusion is applied. The very best pharmacy is looking forward to helping you make sure your health is in good hands no matter if you need zoloft generic or any other drugs that will help you deal with your symptoms in the most efficient way.
The goal of the present paper is to review a clinical case of primary intestinal lymphangiectasia and investigate the mechanisms by which octreotide could act to modify the course of this often difficult to manage clinical entity.