All patients with polyradiculoneuropathy (Guillain-Barre syndrome) had abnormal electrophysiologic studies of the diaphragm, the details of which have been previously described. The amplitude of the diaphragmatic response was significantly decreased bilaterally. In two, the phrenic nerves were totally inexcitable during the height of the illness. When the diaphragmatic responses were elicitable, the latencies were usually prolonged. Two patients had serial studies starting less than a week from the onset of Guillain-Barre syndrome. In both, the diaphragmatic potential regained normal amplitude over several weeks parallel with the improvement in the patients ventilation; however, the latencies of the diaphragmatic responses remained prolonged. The only patient with myasthenia gravis in this series had his diaphragmatic responses decreased in amplitude bilaterally, but the latencies were normal.

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